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Clinical trials for Circulatory System

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43871   clinical trials with a EudraCT protocol, of which   7289   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    60 result(s) found for: Circulatory System. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2013-002189-38 Sponsor Protocol Number: 44945 Start Date*: 2017-10-11
    Sponsor Name:Erasmus Medical Center
    Full Title: OPTIMIZING PERIPHERAL CIRCULATION WITH VASODILATOR THERAPY IN CRITICALLY ILL PATIENTS WITH CIRCULATORY SHOCK: A PILOT STUDY
    Medical condition: Circulatory shock
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012639-13 Sponsor Protocol Number: 28180 Start Date*: 2009-06-29
    Sponsor Name:Meander Medical Centre
    Full Title: Combined intracutaneous and intraperitoneal anaesthesia for postoperative pain reduction after laparoscopic cholecystectomy
    Medical condition: Symptomatic gallstone disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10018109 Generalized convulsive epilepsy LLT
    9.1 10007647 Cardiovascular collapse LLT
    9.1 10002199 Anaphylactic shock LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000958-56 Sponsor Protocol Number: 2019/375 Start Date*: 2019-08-16
    Sponsor Name:Helse Fonna
    Full Title: “Haemodynamic stability during induction of general anesthesia with propofol and remifentanil: A randomized, controlled, double-blind study comparing low vs high propofol doses.”
    Medical condition: In daily clinical work we observe a hypotensive effect and a reduction in HR when induction of general anesthesia is performed using propofol and remifentanil. It is difficult to differentiate the ...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005893-93 Sponsor Protocol Number: 00909.043 Start Date*: 2021-09-21
    Sponsor Name:Uniwersytet Medyczny w Białymstoku
    Full Title: A randomized, double-blind, placebo-controlled study evaluating levosimendan re-infusions in patients with severe heart failure with reduced left ventricular ejection fraction.
    Medical condition: Ambulatory Heart Failure Patients
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10074631 Systolic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004273-88 Sponsor Protocol Number: ASK-1-2011 Start Date*: 2011-09-21
    Sponsor Name:Erling Bjerregaard Pedersen, Medicinsk forskningsafsnit, Regionshospitalet Holstebro
    Full Title: Effect of hydroxyethyl starch on renal handling of sodium and water, vasoactive hormones,biomarkers and the circulatory system in patients undergoing laparoscopic nephrectomy
    Medical condition: Patients undergoing laparoscopic nefrectomy in generel anesthesia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10037775 Radical nephrectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-004906-12 Sponsor Protocol Number: ASK-3-2011 Start Date*: 2011-11-07
    Sponsor Name:Erling Bjerregaard Pedersen, Medicinsk forskningsafsnit, Regionshospitalet Holstebro
    Full Title: Effect of hydroxyethyl starch on renal handling of sodium and water, vasoactive hormones,biomarkers and the circulatory system in patients undergoing hip replacement surgery
    Medical condition: Patients undergoing hip replacement in spinal anesthesia
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10003397 Arthroplasty of hip LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002342-23 Sponsor Protocol Number: 58166 Start Date*: 2016-07-29
    Sponsor Name:VU University Medical Center
    Full Title: The cardiovascular dose-response to supplemental oxygen in healthy volunteers
    Medical condition: Healthy cardiovascular system
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-001401-25 Sponsor Protocol Number: QHD00012 Start Date*: 2019-09-27
    Sponsor Name:Sanofi Pasteur Inc.
    Full Title: Relative Effectiveness of a High-Dose Quadrivalent Influenza Vaccine versus a Standard-Dose Quadrivalent Influenza Vaccine in Subjects 65 Years of Age and Older
    Medical condition: Prevention of influenza infection in adults from 65 years of age and older
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10022000 Influenza PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-000122-21 Sponsor Protocol Number: SJ-193 Start Date*: 2012-08-10
    Sponsor Name:Department of Neurology, Roskilde Hospital
    Full Title: Acethylcholineesterase inhibition and orthostatic hypotension in patients with parkinsons disease
    Medical condition: Ortostatic hypotension in patients with Parkinsons disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10031127 Orthostatic hypotension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-004560-21 Sponsor Protocol Number: NL_ABR-43379 Start Date*: 2013-04-03
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: The effect of ticagrelor on the adenosine system
    Medical condition: We will study in healthy volunteers the effect of ticagrelor on the vasodilator effect of dipyridamole
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-004460-66 Sponsor Protocol Number: KARAASS-1 Start Date*: 2014-04-01
    Sponsor Name:Jørgen Jeppesen
    Full Title: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system
    Medical condition: Blood pressure regulation and hypertension
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004866 10008393 Change in blood pressure LLT
    16.1 100000004865 10053967 Potassium supplementation LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-002416-27 Sponsor Protocol Number: INFECIR2 Start Date*: 2013-10-23
    Sponsor Name:Fundacio Clinic per a la recerca biomedica
    Full Title: Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mo...
    Medical condition: Patients with advanced cirrhosis (serum creatinine > 1.2 mg/dl, serum sodium < 130 mEq/l and/or serum bilirubin > 4 mg/dl), signs of systemic inflammation and urinary infection, pneumonia, skin/sof...
    Disease: Version SOC Term Classification Code Term Level
    16.0 10019805 - Hepatobiliary disorders 10024667 Liver cirrhosis LLT
    16.0 10019805 - Hepatobiliary disorders 10008954 Chronic liver disease and cirrhosis LLT
    16.0 10019805 - Hepatobiliary disorders 10019641 Hepatic cirrhosis PT
    16.0 10019805 - Hepatobiliary disorders 10064704 Decompensated cirrhosis LLT
    16.0 10019805 - Hepatobiliary disorders 10009213 Cirrhosis of liver LLT
    16.0 10019805 - Hepatobiliary disorders 10009211 Cirrhosis liver LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Ongoing) ES (Ongoing) IT (Prematurely Ended) BE (Prematurely Ended) DE (Prematurely Ended) AT (Prematurely Ended) DK (Prematurely Ended) IE (Prematurely Ended) GB (Prematurely Ended) NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-004610-29 Sponsor Protocol Number: 2014.001 Start Date*: 2015-02-18
    Sponsor Name:Skanes University Hospital
    Full Title: Ciclosporin to Protect Renal function In Cardiac Surgery. CiPRICS. A Phase II Double Blind Randomized Placebo Controlled Study.
    Medical condition: Renal dysfunction after CABG surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2014-003468-19 Sponsor Protocol Number: NL50040.029.14 Start Date*: 2015-01-08
    Sponsor Name:VU University Medical Center
    Full Title: The effects of hyperoxia on organ dysfunction and outcome in critically ill patients with SIRS
    Medical condition: Intensive Care patients with the systemic inflammatory response syndrome
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004867 10062357 SIRS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003050-41 Sponsor Protocol Number: HJE-PHARMA-001 Start Date*: 2015-11-10
    Sponsor Name:Rigshospitalet
    Full Title: Efficacy of GLP-1 agonists and restrictive vs. liberal FiO2 in patients undergoing coronary artery bypass grafting or aortic valve replacement – a 2-by-2 factorial designed, randomized clinical study
    Medical condition: We investigate the efficacy of commercially available GLP-1 analog for reducing organ damage in patients undergoing heart surgery (i.e. coronary artery bypass grafting and/or aortic valve replaceme...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000011627 10008937 Chronic ischemic heart disease, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004274-28 Sponsor Protocol Number: ASK-2-2011 Start Date*: 2011-09-21
    Sponsor Name:Erling Bjerregaard Pedersen, Medicinsk forskningsafsnit, Regionshospitalet Holstebro
    Full Title: Effect of hydroxyethyl starch on renal handling of sodium and water, vasoactive hormones,biomarkers and the circulatory system in patients undergoing radical prostatectomy
    Medical condition: Patients undergoing radical prostatectomy in generel anesthesia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10007113 Cancer of prostate LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000328-85 Sponsor Protocol Number: FINNHT1 Start Date*: 2017-05-18
    Sponsor Name:Helsinki University Hospital, Obstetrics and Gynecology
    Full Title: Randomized comparative trial between abrupt and tapered mode of discontinuation of longterm hormone therapy: Impact on endothelial function, recurrence of vasomotor symptoms and quality of life
    Medical condition: We will assess the effects of hormone therapy termination on endothelial function using biophysical (flow-mediated dilation, peripheral artery tonometry) and biochemical markers. We will compare th...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038604 - Reproductive system and breast disorders 10027311 Menopause flushing LLT
    20.0 10041244 - Social circumstances 10076936 Impaired quality of life PT
    20.1 10038604 - Reproductive system and breast disorders 10027301 Menopausal hot flushes LLT
    20.1 10022891 - Investigations 10060858 Cardiovascular function test PT
    20.0 10041244 - Social circumstances 10027308 Menopause PT
    16.1 10038604 - Reproductive system and breast disorders 10027309 Menopause and related conditions HLGT
    20.0 10007541 - Cardiac disorders 10007649 Cardiovascular disorder PT
    20.0 10041244 - Social circumstances 10051775 Postmenopause PT
    20.0 10047065 - Vascular disorders 10048554 Endothelial dysfunction PT
    Population Age: Adults Gender: Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001131-31 Sponsor Protocol Number: FHC-1-2012 Start Date*: 2012-06-14
    Sponsor Name:Department of Medical Research
    Full Title: Effekts of nebivolol on the nitric oxide system in patients with essentiel hypertension
    Medical condition: Essential Hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-002752-20 Sponsor Protocol Number: LAN_POAF_01 Start Date*: 2020-12-17
    Sponsor Name:Medical University of Vienna
    Full Title: A prospective, randomized, double- blind, placebo- controlled study to evaluate the efficacy of Landiolol hydrochloride for prevention of atrial fibrillation in patients undergoing cardiac surgery
    Medical condition: Perioperative atrial fibrillation (POAF) is the most common arryhthmia after cardiac surgery with incidences ranging from 20% to 40%, depending on various patient's risk factors and the type of sur...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005600-19 Sponsor Protocol Number: APHP200072 Start Date*: 2022-06-17
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Full Title: LEvOsimendaN vs. Placebo Before Tricuspid VAlve Surgery in Patients with Right Ventricular Dysfunction
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10068176 Coronary artery bypass graft LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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